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α-Cyano-4-hydroxycinnamic acid

CAS No. : 28166-41-8

MCE 站：α-Cyano-4-hydroxycinnamic acid

产品活性：α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) 是有效的非竞争性单羧酸盐转运蛋白 (MCTs) 抑制剂。α-Cyano-4-hydroxycinnamic acid 抑制线粒体丙酮酸转运蛋白，K_i 值为 6.3 μM。α-Cyano-4-hydroxycinnamic acid 用作基质辅助激光解吸电离-飞行时间质谱 (MALDI-TOF) 分析的基质，可以促进肽离子化。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Monocarboxylate Transporter

In Vitro: α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) inhibits monocarboxylates transport such as lactate and pyruvate.
α-Cyano-4-hydroxycinnamic acid (CHC; 0.5 mM and 1 mM) of 1 mM has a significant inhibitory effect on branching morphogenesis and decreases the epithelial perimeter and area of lung explants in a dose dependent way.
At 100 μM concentration, α-Cyano-4-hydroxycinnamic acid rapidly and almost totally inhibits O₂ uptake by rat heart mitochondria oxidizing pyruvate. Inhibition can be detected at concentrations of inhibitor as low as 1 μM although inhibition took time to develop at this concentration. Inhibition can be reversed by diluting out the inhibitor.

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