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Dicyclomine hydrochloride

CAS No. : 67-92-5

MCE 站：Dicyclomine hydrochloride

产品活性：Dicyclomine hydrochloride 是一种有效的口服活性毒蕈碱胆碱能受体 (muscarinic cholinergic receptors) 拮抗剂。Dicyclomine hydrochloride 对 M1 受体亚型 (K_i=5.1 nM) 和 M2 受体亚型 (K_i=54.6 nM) 在刷缘膜和基底质膜中均表现出较高的亲和力。Dicyclomine hydrochloride是一种抗痉挛试剂，在体内可缓解胃肠道平滑肌痉挛。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：mAChR

In Vivo: Dicyclomine hydrochloride (intraperitoneal?injection; 8 mg/kg; daily) exacerbates the cognitive impairments in all the measurements. In addition, the memory impairments are worse in dicyclomine-treated 3xTg-AD mice compared to dicyclomine-treated NonTg mice.
Dicyclomine hydrochloride (intraperitoneal injection; 2.0, 4.0, and 8.0 mg/kg; 7 days) produces a highly significant effect on performance in the paired-associates learning (PAL) task in mice.And systemic treatment at lower doses show behavioral impairments in mice in spatial tasks.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Neuronal Signaling Compound Library  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  Lipid Compound Library  |  Orally Active Compound Library  |  Neurotransmitter Receptor Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Clozapine N-oxide  |  Deschloroclozapine  |  Pilocarpine Hydrochloride  |  Atropine  |  Olanzapine  |  Amitriptyline hydrochloride  |  Levetiracetam  |  Carbamoylcholine chloride  |  Darifenacin hydrobromide  |  Methacholine chloride  |  Otilonium bromide  |  DREADD agonist 21  |  Peimisine  |  Propantheline bromide  |  Cevimeline hydrochloride hemihydrate  |  Dronedarone  |  L-Hyoscyamine  |  Tiotropium Bromide  |  Xanomeline oxalate  |  Anethole trithione  |  Metixene hydrochloride hydrate  |  Trospium chloride  |  Bethanechol chloride  |  Biperiden Hydrochloride  |  Pirenzepine dihydrochloride  |  Diphenidol hydrochloride  |  Ipratropium bromide

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