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Cefuroxime

CAS No. : 55268-75-2

MCE 站：Cefuroxime

产品活性：Cefuroxime 是一种具有口服活性的第二代头孢菌素抗生素 (antibiotic)，增加了对 β-内酰胺酶 (β-lactamase) 的稳定性。Cefuroxime 具有广谱的抑制活性，对革兰氏阳性菌和革兰氏阴性菌都有效。

研究领域：Anti-infection

作用靶点：Bacterial  |  Antibiotic

In Vitro: Cefuroxime is highly active against S. aureus (MIC=0.25 μg/ml), regardless of whether the strains produces a penicillinase. It is against Staphylococcus aureus methicillin susceptible; S. aureus, methicillin resistant, Streptococcus pyogenes, S. pneumoniae, S. viridans, S. faecalis, and Clostridium spp with MIC values of 0.25 μg/ml, 5.9 μg/ml, 0.125 μg/ml, 0.125 μg/ml, 0.125 μg/ml, >125.0 μg/ml, and 1.2 μg/ml, respectively.
Cefuroxime (10-100 μg/ml; 2-6 hours) rapidly bactericidal, its action is comparatively slow against the strains of S. aureus, but, even so, over 99% of the initial inoculum is killed by 6 h. The gram-negative organisms are killed rapidly, and in most cases over 99% of the very large inocula are killed within 2 h; the β-lactamase-producing strains are killed as quickly as non-enzyme-producing strains.

In Vivo: Rabbits (weighing 2.0 to 2.5 kg) are challenged intravenously with S. aureus strain 630 (a penicillinase-producing strain), the median effective dose of Cefuroxime is 3 mg/kg as a result of the protection test.

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