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SP-141

CAS No. : 1253491-42-7

MCE 站：SP-141

产品活性：SP-141 是一种特异性的 MDM2 抑制剂。SP-141 促进 MDM2 自泛素化和降解。SP-141 可用于胰腺癌和乳腺癌的研究。

研究领域：Apoptosis

作用靶点：MDM-2/p53

In Vitro: SP-141 (0.01-10 μM; 72 hours) inhibits human pancreatic cancer cell growth with IC₅₀ values of less than 0.5 μM (0.38-0.50 μM) in a p53-independent manner. The IMR90 cells are much less sensitive to SP141 than the pancreatic cancer cells, suggesting that SP141 has a selective cytotoxicity for cancer cells.
SP141 induces MDM2 auto-ubiquitination and proteasomal degradation in both HPAC and Panc-1 cells.

In Vivo: SP-141 (40 mg/kg; administered by i.p. injection; 5 d/wk for about three weeks) suppresses pancreatic tumor growth in both xenograft and orthotopic mouse models.

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