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TCS PIM-1 1

CAS No. : 491871-58-0

MCE 站：TCS PIM-1 1

产品活性：TCS PIM-1 1 (SC 204330) 是一种有效的，具有选择性和 ATP 竞争性的 Pim-1 激酶抑制剂，IC₅₀ 为 50 nM，对 Pim-2 和 MEK1/MEK2 表现出良好的选择性 (IC₅₀ >20000 nM)。

研究领域：JAK/STAT Signaling

作用靶点：Pim

In Vitro: TCS PIM-1 1 (compound 1), a substituted pyridone scaffold, binds convincingly within the ATP-binding site of Pim-1 suggesting an ATP-competitive inhibitory mechanism. Preliminary data further suggests that TCS PIM-1 1 lacked in vitro inhibitory activity toward related serine/threonine kinases Pim-2 and MEK1/2. Hence, small molecules similar to TCS PIM-1 1 may serve as useful starting scaffolds for the development of other improved yet selective Pim-1 inhibitors. TCS PIM-1 1 serves both as a starting point for SAR chemical syntheses and was used for co-crystallization with Pim-1 protein.

相关产品：Bioactive Compound Library Plus  |  Epigenetics Compound Library  |  Immunology/Inflammation Compound Library  |  JAK/STAT Compound Library  |  Kinase Inhibitor Library  |  Anti-Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  PIM-447 dihydrochloride  |  Pim1/AKK1-IN-1  |  Hispidulin  |  TCS-PIM-1-4a  |  Quercetagetin  |  M-110  |  SMI-16a  |  CK2/ERK8-IN-1  |  CK2/PIM1-IN-1  |  CX-6258 hydrochloride  |  R8-T198wt

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