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Sertraline hydrochloride

CAS No. : 79559-97-0

MCE 站：Sertraline hydrochloride

产品活性：Sertraline hydrochloride 是一种选择性 5- 羟色胺再吸收抑制剂 (SSRI) 类的抗抑郁剂。Sertraline hydrochloride 用于研究多种疾病，例如重度抑郁症和强迫症。

研究领域：Neuronal Signaling

作用靶点：Serotonin Transporter

In Vitro: Sertraline (1 μM, 12 hours) inhibits high mobility group box 1 (HMGB1)- or tumor necrosis factor-α (TNF-α)-induced microglial activation and inflammatory mediator production in microglia.
Sertraline (1 μM) inhibits the HMGB1/toll-like receptor 4 (TLR4)- and TNF-α/TNF receptor 1 (TNFR1)-mediated nuclear factor-kappa B (NF-κB) activation in HMGB1- or TNF-α-stimulated microglia.

In Vivo: Sertraline (10 mg/kg) is shown to produce the optimal anti-depression effectsin chronic unpredictable mild stress (CUMS)-exposed mice.
Sertraline (10 mg/kg; a single i.p.) significantly reduces the immobility time during forced swim test (FST) in all female animals.
Sertraline (10 mg/kg; a single i.p.) does not alter spontaneous locomotor activity in all three genotypes regardless of sex difference.

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