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Imeglimin hydrochloride

CAS No. : 775351-61-6

MCE 站：Imeglimin hydrochloride

产品活性：Imeglimin hydrochloride (EMD 387008 hydrochloride) 是一种口服降糖剂。Imeglimin 可改善胰岛素敏感性。Imeglimin 还减少活性氧 (ROS) 的产生，增加了线粒体 DNA，并改善线粒体功能。

研究领域：Metabolic Enzyme/Protease  |  NF-κB  |  Immunology/Inflammation

作用靶点：Mitochondrial Metabolism  |  Reactive Oxygen Species

In Vitro: Preincubation with Imeglimin (10?mM for 4?h or 100?μM for 24?h) also fully prevented tert-butylhydroperoxide (tBH)-induced cell death.

In Vivo: Imeglimin (200 mg/kg b.i.d. by oral gavage during the last 6 weeks of HFHSD feeding) significantly decreases hyperglycemia, and restores normal glucose tolerance.

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