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Xanomeline oxalate

CAS No. : 141064-23-5

MCE 站：Xanomeline oxalate

产品活性：Xanomeline oxalate (LY246708 oxalate) 是一种有效的、选择性毒蕈碱受体激动剂 (SMRA)，可刺激体内的磷酸肌醇水解。 Xanomeline oxalate 可用于研究阿尔茨海默氏病。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：mAChR

In Vitro: Xanomeline stimulates phosphoinositide (PI) hydrolysis in the A9 L m1 cells.
Xanomeline inhibits [³H]-pirenzepine ([³H]-PZ) and [³H]-oxotremorine-M ([³H]-OXO-M) binding to rat brain with K_is of 7 and 3 nM, respectively.

In Vivo: Xanomeline robustly stimulates in vivo PI hydrolysis and the effect is blocked by muscarinic antagonists, demonstrating mediation by muscarinic receptors. In mice the ED₁₀₀ for Xanomeline-induced stimulation of [³H]-IP accumulation is 54 μmole/kg in hippocampus. And in rats the ED₁₀₀ for Xanomeline-induced stimulation of [³H]-IP accumulation is 8.1 μmole/kg in hippocampus.

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