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Venlafaxine hydrochloride

CAS No. : 99300-78-4

MCE 站：Venlafaxine hydrochloride

产品活性：Venlafaxine hydrochloride (Wy 45030 hydrochloride) 是口服有效的 5-羟色胺 (5-HT)/去甲肾上腺素 (NE) 重摄取的双重抑制剂。Venlafaxine 具有抗抑郁作用。

研究领域：Neuronal Signaling

作用靶点：Serotonin Transporter

In Vitro: Venlafaxine hydrochloride (Wy 45030 hydrochloride) dose-dependently inhibits binding of the serotonin transporter radioligand [^3H]-paroxetine to membranes from cells transfected with the human 5-HT transporter with a K_i of 2.48 μM. Venlafaxine hydrochloride inhibits binding of the NE transporter ligand [^3H]-nisoxetine to membranes from cells transfected with the human NE transporter with a K_i of 82 nM.
Venlafaxine hydrochloride inhibits ex vivo binding to rat 5-HT transporters and NE transporters with ED₅₀ values of 2 and 54 mg/kg, respectively.

In Vivo: Venlafaxine hydrochloride (Wy 45030 hydrochloride; 10-100 mg/kg; IP) dose-dependently blocks the depletion of norepinephrine levels in rat hypothalamus induced by 6-OHDA.

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