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SAR7334 hydrochloride

CAS No. : 1333207-63-8

MCE 站：SAR7334 hydrochloride

产品活性：SAR7334 hydrochloride 是一种有效的 TRPC6 特异性抑制剂，能够抑制 TRPC6 电流，IC₅₀ 值为 7.9 nM。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：TRP Channel

In Vitro: SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca²⁺ influx into cells with IC₅₀s of 9.5, 282 and 226?nM, whereas TRPC4 and TRPC5-mediated Ca²⁺ entry is not affected. SAR7334 (1?μM) results in a major block of the Ang II-evoked calcium influx in the podocytes. SAR7334 (1 μM) has negligible effect on SOCE. SAR7334 dose-dependently reduces TRPC6 currents with an IC₅₀ of 7.9?nM. SAR7334 (100?nM) substantially reduces TRPC6 currents.

In Vivo: SAR7334 (10?mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR).

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