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Raf inhibitor 1

CAS No. : 1093100-40-3

MCE 站：Raf inhibitor 1

产品活性：Raf inhibitor 1是一种有效的 Raf 激酶抑制剂，作用于 B-Raf^WT, B-Raf^V600E, 和 C-Raf, K_i 分别为 1 nM, 1 nM, 和 0.3 nM。

研究领域：MAPK/ERK Pathway

作用靶点：Raf

In Vitro: Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC₅₀s of 0.31 and 0.72 μM, respectively. Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif. Raf inhibitor 1 (Compound 13) additionally exhibits low micromolar inhibition against wild type B-Raf cell lines, which may be due to off-target kinase activities or alternatively to pan-Raf inhibition, including Raf dimers.

相关产品：Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  MAPK Compound Library  |  Anti-Cancer Compound Library  |  Oxygen Sensing Compound Library  |  Ferroptosis Compound Library  |  Glutamine Metabolism Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Doramapimod  |  GW 5074  |  Ro 5126766  |  AZ 628  |  GDC-0879  |  ZM 336372  |  Agerafenib  |  AZ304  |  L-779450  |  MCP110  |  Sorafenib (D3)  |  Raf inhibitor 1 dihydrochloride  |  Raf inhibitor 2

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