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Meloxicam

CAS No. : 71125-38-7

MCE 站：Meloxicam

产品活性：Meloxicam 是一种非甾体类抗炎剂，能够有效抑制 COX 的活性，对 COX-2 和 COX-1 的 IC₅₀ 值分别为 0.49 ?M 和 36.6 ?M。

研究领域：Immunology/Inflammation  |  Autophagy  |  Apoptosis

作用靶点：COX  |  Autophagy  |  Apoptosis

In Vitro: Meloxicam (Compound 5) is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC₅₀s of 0.49 ?M and 36.6 ?M for COX-2 and COX-1, respectively. Meloxicam inhibits COX⁺ tumor cells, but shows no cytotoxicity on CF41.Mg or MDCK cells at 0.25-25 ?g/mL. Furthermore, Meloxicam in combination with doxorubicin, has no synergistic effect on CF41.Mg cells. Meloxicam (0.25 ?g/mL) decreases CF41.Mg cell migration and invasion, induces decrease in MMP-2 expression, and increases β-catenin phophorylation in CF41.Mg cells, but does not affect the CF41.Mg cell apoptosis.

In Vivo: Meloxicam (10 mg/kg) alone or in combination with rutin significantly decreases paw liking time on 1st day by 55% and 49% compared with the formalin-treated group, respectively, however the combination reduces time non-significantly on 3rd day in mice. Meloxicam alone or in combination with rutin also decreases relative liver weights, reduces MDA contents, induces liver SOD activities, hampers IL-1β content, and significantly reduces the number of positive caspase-3 immunoreactive cells in mice.

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