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Telotristat ethyl

CAS No. : 1033805-22-9

MCE 站：Telotristat ethyl

产品活性：Telotristat ethyl (LX1032) 是一种可口服的色氨酸羟化酶抑制剂，能够减少血清素的产生。

研究领域：Metabolic Enzyme/Protease

作用靶点：Tryptophan Hydroxylase

In Vivo: Telotristat ethyl (15, 50, 150, 300 mg/kg, po, qd) reduces serotonin content in the periphery, but not in the brain of the mice. Telotristat ethyl (200 mg/kg po, qd) prevents the increase in blood neutrophil counts that is observed after TNBS challenge, provides significant protection in a mouse model of inflammatory bowel disease. Telotristat ethyl (200 mg/kg po, qd) protects the mouse IBD model confirmed by histopathology evaluation. Telotristat ethyl (15, 50, 150, 300 mg/kg) depletes 5-HT from the jejunum but not the brain. But Telotristat ethyl (200 mg/kg, p.o.) does not deplete enteric neuronal serotonin (5-HT), or alter constitutive gastrointestinal motility in mice. Telotristat ethyl (200 mg/kg) alleviates the severity of trinitrobenzene sulfonic acid (TNBS)-induced colitis.

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