MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Dapoxetine hydrochloride

CAS No. : 129938-20-1

MCE 站：Dapoxetine hydrochloride

产品活性：Dapoxetine (LY-210448) hydrochloride 是一种具有口服活性的选择性血清素再摄取 (serotonin reuptake) 抑制剂 (SSRI)。Dapoxetine hydrochloride 可用于早泄 (PE) 的相关研究。

研究领域：Neuronal Signaling

作用靶点：Serotonin Transporter

In Vitro: Dapoxetine hydrochloride binds to 5-HT, norepinephrine, and dopamine reuptake transporters and inhibits 5-HT, norepinephrine, and dopamine uptake with an order of potency: 5-HT >norepinephrine?dopamine.
Dapoxetine hydrochloride inhibits the uptake of [³H]5-HT by the 5-HT reuptake transporter with a value of 1.12 nM, and Dapoxetine inhibits the uptake of [³H]norepinephrine into cells utilizing the norepinephrine reuptake transporter and uptake of [³H]dopamine by the dopamine reuptake transporter with IC₅₀ values of 202 nM and 1720 nM, respectively.

In Vivo: Dapoxetine hydrochloride (oral gavage; 1-10 mg/kg; once daily) significantly inhibits testosterone mediated increase in the prostate weight and relative prostate weight and attenuates testosterone-induced prostatic hyperplasia in rats.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Neuronal Signaling Compound Library  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  Anti-COVID-19 Compound Library  |  NMPA-Approved Drug Library  |  FDA Approved & Pharmacopeial Drug Library  |  Paroxetine hydrochloride  |  Fluvoxamine maleate  |  Imipramine hydrochloride  |  Sertraline hydrochloride  |  Desipramine hydrochloride  |  Duloxetine hydrochloride  |  Amitriptyline hydrochloride  |  Escitalopram oxalate  |  Clomipramine hydrochloride  |  Citalopram hydrobromide  |  Vilazodone  |  Venlafaxine hydrochloride  |  Milnacipran hydrochloride  |  Amitifadine hydrochloride  |  Azaphen dihydrochloride monohydrate  |  Cinchonidine  |  (S)-Venlafaxine  |  Dapoxetine-D7 hydrochloride

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。