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Carbidopa

CAS No. : 28860-95-9

MCE 站：Carbidopa

产品活性：Carbidopa ((S)-(-)-Carbidopa) 是一种外周型脱羧酶 (decarboxylase) 抑制剂，可用于帕金森病的研究。Carbidopa 是一种选择性芳香烃受体 (AhR) 调节剂。Carbidopa 抑制胰腺癌细胞和肿瘤生长。

研究领域：Immunology/Inflammation

作用靶点：Aryl Hydrocarbon Receptor

In Vitro: Carbidopa ((S)-(-)-Carbidopa) exhibits activities similar to that described for other AhR ligands in BχPC3 and Capan-2 cells, namely the induction of CYP1A1 and CYP1A2, which are inhibited by AhR antagonists such as CH223191.

In Vivo: Carbidopa also induces nuclear uptake of the AhR, and in vivo studies show that carbidopa at a dose of 1 mg/mouse significantly inhibits tumor growth in athymic nude mice bearing BχPC3 cells as xenografts.

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