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Hydroxyurea

CAS No. : 127-07-1

MCE 站：Hydroxyurea

产品活性：Hydroxyurea 通过抑制核糖核苷酸还原酶抑制 DNA 合成的细胞凋亡诱导剂。

研究领域：Cell Cycle/DNA Damage  |  Autophagy  |  Apoptosis  |  Anti-infection

作用靶点：DNA/RNA Synthesis  |  Autophagy  |  Apoptosis  |  HIV

In Vitro: Hydroxyurea is used in a number of myeloproliferative, neoplastic, HIV, and non-hematological diseases. Treatment of cells in primary culture with 30 μM hydroxyurea for 96 hours significantly increases the fractional HbF content. The ^Gγ: ^Aγ-globin mRNA is induced 0.30- to 8-fold in vitro. Hydroxyurea has been shown to block HIV-1 reverse transcription and/or replication in quiescent peripheral blood mononuclear cells and macrophages.

In Vivo: Hydroxyurea therapy producs consistent reductions in WBC and ANC without improvement in anemia over 17 weeks. Hydroxyurea at 50mg/kg produces a reduced white blood cell count, absolute neutrophil count and no improvement in anemia compared to vehicle treated sickle cell mice.

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