MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Inauhzin

CAS No. : 309271-94-1

MCE 站：Inauhzin

产品活性：Inauhzin 是 SirT1/IMPDH2 的双重抑制剂，同时为 p53 的激活剂，可用于癌症研究。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics  |  Apoptosis

作用靶点：Sirtuin  |  MDM-2/p53

In Vitro: Inauhzin (10 ?M) induces p53 levels as effectively as actinomycin D (10 nM), and mediates p53-dependent cytotoxicity through its specific functional groups in human lung carcinoma H460 cells. Inauhzin (2 ?M) induces p53 level and activity as well as p53-dependent apoptosis. Inauhzin also stabilizes p53 and inhibits its ubiquitylation. Inauhzin induces acetylation of p53 in H460 cells, but not tubulin, which is affected by knockdown of SIRT1. Inauhzin (0-2 ?M) significantly enhances the expression level and activity of p53 in HCT116^p53+/+ cells and enhances the expression level and activity of p53 in H460 cells in a dose-dependent manner. Inauhzin and Nutlin-3 demonstrate synergistic cytotoxicity in the Nutlin-3 low-sensitive cells. Inauhzin and Nutlin-3 synergistically induce p53-dependent apoptosis. Inauhzin targets both SirT1 and IMP dehydrogenase 2 (IMPDH2), and acts as a potent p53 activator.

In Vivo: Inauhzin (30 mg/kg, i.p.) effectively induces apoptosis and suppresses tumour growth of H460 xenograft harbouring p53. Inauhzin (30 mg/kg, i.p.) reduces the HCT116 tumor volume by appr 70%. Inauhzin (15 mg/kg) in combination with 150 mg/kg of Nutlin-3 demonstrates a significant synergy on p53 induction, apoptosis and tumor suppression of HCT116^p53+/+ xenografts.

相关产品：Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  Cell Cycle/DNA Damage Compound Library  |  Epigenetics Compound Library  |  Histone Modification Research Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Ferroptosis Compound Library  |  Pyroptosis Compound Library  |  Glutamine Metabolism Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Resveratrol  |  Selisistat  |  Nicotinamide  |  Nicotinamide riboside chloride  |  Nutlin-3a  |  Pifithrin-α hydrobromide  |  3-TYP  |  Eprenetapopt  |  Suramin sodium salt  |  OSS_128167  |  Fisetin  |  UBCS039  |  Sirtinol  |  Amifostine  |  Pifithrin-μ  |  RITA  |  CAY10602  |  AGK2  |  MI-773  |  Pifithrin-α, p-Nitro, Cyclic  |  AK-7  |  SIRT5 inhibitor 1  |  Cambinol  |  MC3482  |  NSC319726  |  Amifostine thiol dihydrochloride  |  Ganoderic acid D

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。