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Adiphenine hydrochloride

CAS No. : 50-42-0

MCE 站：Adiphenine hydrochloride

产品活性：Adiphenine hydrochloride 是一种非竞争性的烟碱乙酰胆碱受体 (nAChR) 抑制剂，对 α1，α3β4，α4β2 和 α4β4 的 IC₅₀ 值分别为 1.9，1.8，3.7 和 6.3 ?M。Adiphenine hydrochloride 具有局部麻醉和抗惊厥作用。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：nAChR

In Vitro: Adiphenine (10 nM-1 mM; 3 min) blocks the function of α1*-nAChR in a dose-dependent manner in TE671/RD cells, with an IC₅₀ of 1.9 ?M.
Adiphenine (10 nM-1 mM; 3 min) blocks the function of α3α4*-nAChR in a dose-dependent manner in SH-SY5Y cells, with an IC₅₀ of 1.8 ?M.
Adiphenine (10 nM-1 mM; 3 min) blocks the function of α4β2- and α4β4-nAChR in a dose-dependent manner in SH-EP1 cells, with IC₅₀s of 3.7 and 6.3 ?M, respectively.
Adiphenine (50-200 ?M; 30-60 s) decreases the frequency of ACh-induced single-channel currents in HEK 293 cells.

In Vivo: Adiphenine (i.p.) prevents the hindleg tonic-extensor component of maximal electroshock seizures (MES), with an ED₅₀ of 62 mg/kg in mice.

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