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AR 231453

CAS No. : 733750-99-7

MCE 站：AR 231453

产品活性：AR 231453 是有效的、特异性的、具有口服活性的 GPR119 激动剂。AR 231453 可刺激细胞增殖，改善胰岛 β 细胞的功能。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：GPR119

In Vitro: AR 231453 is inactive at all other GPCRs tested (more than 230, including all known pancreatic islet receptors), indicating that it is highly selective for GPR119.
AR 231453 potently stimulats cAMP accumulation (EC₅₀ = 4.7 nM) with a maximal efficacy similar to that seen with forskolin. AR 231453 significantly enhancesinsulin release in HIT-T15 cells, with an EC₅₀ of 3.5 nM.
AR 231453 also stimulates insulin release in isolated mouse islets at glucose concentrations ranging from 8-17 mM.

In Vivo: AR231453 (20 mg/kg, orally) markedly improves oral glucose tolerance in a dose-dependent fashion, with efficacy similar to maximally effective doses of the sulfonylurea glyburide.

相关产品：Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Neuronal Signaling Compound Library  |  Orally Active Compound Library  |  APD668  |  AS1269574  |  2-Oleoylglycerol

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