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Dorsomorphin dihydrochloride

CAS No. : 1219168-18-9

MCE 站：Dorsomorphin dihydrochloride

产品活性：Dorsomorphin dihydrochloride (Compound C dihydrochloride) 是一种有效，选择性和 ATP 竞争性的 AMPK 抑制剂，K_i 为 109 nM。Dorsomorphin dihydrochloride 通过靶向抑制 I 型受体 ALK2，ALK3 和 ALK6 来抑制 BMP 途径。Dorsomorphin dihydrochloride 诱导自噬 (autophagy) 作用。

研究领域：Epigenetics  |  PI3K/Akt/mTOR  |  TGF-beta/Smad  |  Autophagy

作用靶点：AMPK  |  TGF-β Receptor  |  Autophagy

In Vitro: Dorsomorphin (compound C) (0-10 μM, 18 h) suppresses 2DG-induced GRP78 promoter activity in human fibrosarcoma HT1080 cells in a dose-dependent manner but has little effect on tunicamycin-induced GRP78 promoter activity. Dorsomorphin (compound C) C also suppresses GRP78 promoter activity induced by glucose withdrawal. Dorsomorphin (compound C) has no effect on 2DG-induced PERK activation and reduces the both basal and 2DG-induced AMPK phosphorylation levels in HT1080 cells.

In Vivo: Dorsomorphin (compound C: 10 mg/kg, intravenously once) treatment leads to a 60% increase in total serum iron concentrations, reduces basal levels of hepcidin expression and increasing serum iron concentrations in adult mice.
Dorsomorphin (compound C: 0.2 mg/kg, i.v., 30 min before LPS injection) reduces ICAM-1 and VCAM-1 expression in LPS-injected rat aorta.
Dorsomorphin (compound C; 25 mg/kg; i.p. injection, in male BALB/c mice) treatment before lipopolysaccharide (LPS) injection significantly reduces lethality in contrast to animals treated with LPS challenge only.

相关产品：Bioactive Compound Library Plus  |  Epigenetics Compound Library  |  Kinase Inhibitor Library  |  PI3K/Akt/mTOR Compound Library  |  TGF-beta/Smad Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Endoplasmic Reticulum Stress Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Doxorubicin hydrochloride  |  SB-431542  |  Metformin hydrochloride  |  Dorsomorphin  |  AICAR  |  A 83-01  |  A-769662  |  LDN193189  |  RepSox  |  GSK-690693  |  SB 525334  |  STO-609  |  DMH-1  |  SB-505124  |  Phenformin hydrochloride  |  [6]-Gingerol  |  WZ4003  |  BMP signaling agonist sb4  |  GW788388  |  ITD-1  |  LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA)  |  Palmitelaidic Acid  |  Urolithin B  |  GSK621  |  SD-208

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