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Brompheniramine maleate

CAS No. : 980-71-2

MCE 站：Brompheniramine maleate

产品活性：Brompheniramine ((±)-Brompheniramine) maleate 是一种有效的且具有口服活性的丙胺类抗组胺剂。Brompheniramine maleate 是一种选择性组胺 H1 受体 (histamine H1 receptor) 拮抗剂，K_d 为 6.06 nM。Brompheniramine maleate 具有抗胆碱能，抗抑郁和镇痛作用，可用于过敏性鼻炎的研究。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation

作用靶点：Histamine Receptor

In Vitro: In in vitro experiments, Brompheniramine blocks muscarinic cholinergic receptors in human chinese hamster ovary (CHO) cells, sodium and calcium channels in CHO cells, as well as potassium channels in human embryonic kidney 293 (HEK-293) cells. Brompheniramine suppresses the transfected Nav_1.5 channels from myocytes.

In Vivo: Brompheniramine as an antihistamine blocks sodium channels. Brompheniramine (3.0, 1.5, 1.1, 0.6, and 0.3 μmol) treatment shows cutaneous analgesic effect with an ED₅₀ value of 0.89 in a rat model of infiltration anesthesia. Subcutaneous Brompheniramine induces dose-relatedly analgesic effects, and Brompheniramine induces prolonged analgesic duration.

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