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产品价格:电议      采购度:1589      原产地:美洲
发布时间:2021/7/26 23:52:27 所属地区:上海 上海市
简要描述:
Pancuronium dibromide,一种双季基类固醇,是一种神经肌肉松弛剂。Pancuronium dibromide 通过与乙酰胆碱竞争 nACh 受体上的结合位点来抑制神经肌肉传递。Pancuronium dibromide 还可抑制心脏毒蕈碱受体并具有拟交感神经作用。
标签:Pavulon
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CAS No. : 15500-66-0
MCE 站:Pancuronium dibromide
产品活性:Pancuronium dibromide,一种双季基类固醇,是一种神经肌肉松弛剂。Pancuronium dibromide 通过与乙酰胆碱竞争 nACh 受体上的结合位点来抑制神经肌肉传递。Pancuronium dibromide 还可抑制心脏毒蕈碱受体并具有拟交感神经作用。
研究领域:Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点:nAChR
In Vitro: The action of Pancuronium on transmembrane sodium conductance is investigated in dorsal root ganglion neurones of chick embryos. Externally perfused Pancuronium (50 μM to 1 mM) reversibly inhibits the current by a fast mechanism of action. Inhibition is concentration-dependent (with a half-effective dose of 170 μM) but not voltage-dependent. Pancuronium may reduce the sodium current by interacting with the sodium channels in both the resting and open states.
In Vivo: Pancuronium (0.5 mg/kg; intravenous injection) abolishes the bradycardia induced both by injected acetylcholine (ACh) and by vagal nerve stimulation in guinea-pigs (250-300 g, male). At doses which produce 100% neuromuscular blockade, Pancuronium (0.04 mg/kg) potentiates vagally-induced bronchoconstriction.
Potentiation by Pancuronium of the effects of adrenergic nerve stimulation, is found in rat anococcygeus and vas deferens.
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更新时间:2024/1/2 10:16:09
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