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Pergolide mesylate

CAS No. : 66104-23-2

MCE 站：Pergolide mesylate

产品活性：Pergolide mesylate (Pergolide methanesulfonate)，一种 Ergoline 衍生物，是一种有效的，具有口服活性的多巴胺 D₁ 和 D₂ 受体 (dopamine D₁ 和 D₂ receptors) 激动剂。Pergolide mesylate 可用于帕金森氏病和高泌乳素血症的研究。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Dopamine Receptor

In Vitro: Pergolide (10 nM-50 μM) treatment dose-dependently inhibits H₂O₂-induced cell death in SH-SY5Y neuroblastoma cells. Pergolide protects SH-SY5Y neuroblastoma cells from cell death specifically induced by H₂O₂, acting in very low concentrations (nanomolar range) and in very early stages of the neurotoxic intracellular process.

In Vivo: Pergolide (0.3 mg/kg; intraperitoneal injection; daily; 11 days) treatment reduces the number of working/reference memory errors a 6-OHDA-induced rat model of Parkinson's disease. Pergolide facilitates spatial memory and improves brain oxidative balance .

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