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Lamotrigine

CAS No. : 84057-84-1

MCE 站：Lamotrigine

产品活性：Lamotrigine (BW430C) 是一种有效的，具有口服活性的抗惊厥或抗癫痫试剂 (anticonvulsant agent)。Lamotrigine 选择性地阻断电压门控钠离子通道 (Na⁺ channels)，稳定突触前神经元膜，抑制谷氨酸释放。Lamotrigine 可用于癫痫、局灶性癫痫等的研究。

研究领域：Membrane Transporter/Ion Channel  |  Autophagy

作用靶点：Sodium Channel  |  Autophagy

In Vitro: Lamotrigine inhibits Veratrine evoked release of glutamate and aspartate with ED₅₀ values of 21 μM for both amino acids, but Lamotrigine is less potent in the inhibition of GABA release (ED₅₀=44 μM. At concentrations up to 300 μM, LTG has no effect on patassium-evoked amino acid.
Lamotrigine is some five times less potent in the inhibition of Veratrine-evoked [³H]acetylcholine release (ED₅₀=100 μM) than in glutamate or aspartate release.

In Vivo: Lamotrigine (?intraperitoneally injection 30 min before pentylenetetrazol; 10 mg/kg, 15 mg/kg or 20 mg/kg) decreases the seizure intensity?at the higher doses, it increases the latency to the first pentylenetetrazol-induced seizure?in all studied doses compared with the controls.

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