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Procaine

CAS No. : 59-46-1

MCE 站：Procaine

产品活性：Procaine 是 DNA 脱甲基剂。Procaine 通过多个靶标起作用，起效缓慢，作用持续时间短。

研究领域：Epigenetics  |  Cell Cycle/DNA Damage

作用靶点：Histone Demethylase  |  DNA/RNA Synthesis

In Vitro: Procaine (0.01-100 microM) inhibited the 5-HT3 receptor-mediated inward current in the whole-cell patch clamp recording. Procaine appears to produce a competitive inhibition on 5-HT3 receptors with a KD of 1.7 microM. Procaine is a DNA-demethylating agent that produces a 40% reduction in 5-methylcytosine DNA content as determined by high-performance capillary electrophoresis or total DNA enzyme digestion. Procaine can also demethylate densely hypermethylated CpG islands. Procaine also has growth-inhibitory effects in these cancer cells, causing mitotic arrest. Procaine functions as an excitant of limbic system cells, and that procaine alters synaptic transmission in some, but not all, output pathways from the amygdale.

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