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Travoprost

CAS No. : 157283-68-6

MCE 站：Travoprost

产品活性：Travoprost (Fluprostenol isopropyl ester) 是一种异丙基酯前药，是一种高亲和力的，选择性的 FP 前列腺素全受体激动剂。Travoprost 有降眼压功效，有潜力应用于青光眼和眼高压。

研究领域：GPCR/G Protein

作用靶点：Prostaglandin Receptor

In Vitro: Travoprost has sub-micromolar affinity for the DP, EP1, EP3, EP4, IP, and TP receptors.

In Vivo: Travoprost produces a lower incidence of ocular irritation than PGF20 isopropyl ester at a dose of 1 μg in the New Zealand albino (NZA) rabbit. Topical ocular application of Travoprost produces a marked miotic effect in cats following doses of 0.01, 0.03 and 0.1 μg. In the ocular hypertensive monkey, b.i.d. application of 0.1 and 0.3 μg of travoprost afforded peak reduction in intraocular pressure (IOP) of 22.7% and 28.6%, respectively. Topical application of travoprost was well tolerated in rabbits, cats and monkeys, causing no ocular irritation or discomfort at doses up to 1 μg.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Immunology/Inflammation Compound Library  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  Lipid Compound Library  |  Endocrinology Compound Library  |  Anti-COVID-19 Compound Library  |  NMPA-Approved Drug Library  |  FDA Approved & Pharmacopeial Drug Library  |  Prostaglandin E2  |  Prostaglandin E1  |  Iloprost  |  PF-04418948  |  Tranilast  |  ONO-AE3-208  |  AH 6809  |  U-46619  |  Latanoprost  |  Laropiprant  |  Rebamipide  |  RO1138452  |  Ramatroban  |  p-Hydroxycinnamic acid  |  Bimatoprost  |  Pectolinarin  |  Taprenepag  |  Dinoprost tromethamine salt  |  (+)-Cloprostenol  |  Dazoxiben  |  Evatanepag  |  L-798106  |  Seratrodast  |  Nedocromil  |  Treprostinil  |  CAY10471 Racemate  |  Cloprostenol sodium salt  |  L 888607  |  AZ12672857  |  Prostaglandin D2

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