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产品价格:电议      采购度:1603      原产地:美洲
发布时间:2021/7/27 0:43:36 所属地区:上海 上海市
简要描述:
Piracetam (UCB-6215) 是GABA的环状衍生物,可作用于多种认知障碍。
标签:Nootropil
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CAS No. : 7491-74-9
MCE 站:Piracetam
产品活性:Piracetam (UCB-6215) 是GABA的环状衍生物,可作用于多种认知障碍。
研究领域:Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点:iGluR
In Vitro: Piracetam (UCB-6215) is able to significantly decrease the fusogenic and destabilising effect of Abeta 29-42, in a concentration-dependent manner. Preincubation of piracetam, at a piracetam/peptide ratio of 960, during 20 min before the addition of Abeta 29-42 prevents almost completely the mixture of the two fluorescent probes. Preincubation of piracetam with lipids prevents almost completely the release of calcein induced by the peptide in a dose-dependent fashion (piracetam/peptide ratios from 9.6 to 960).
In Vivo: Piracetam (UCB-6215) (< 1.0 mM) preincubated with brain membranes enhances membrane fluidity in aged mice, rats and humans, as indicated by decreased anisotropy of the membrane-bound fluorescence probe 1,6-diphenyl-1,3,5-hexatriene (DPH). Piracetam (UCB-6215) (300 mg/kg once daily) significantly increases membrane fluidity in some brain regions of young and aged rats, but has no measurable effect on membrane fluidity in the young rats. Piracetam (UCB-6215) (300 mg/kg daily for 6 weeks) improves active avoidance learning in the aged rats only and elevates membrane fluidity in all brain regions except the cerebellum in the aged rats. Piracetam (UCB-6215) (300 mg/kg daily for 6 weeks) also improves NMDA receptor density in the hippocampus and on muscarinic cholinergic receptor densities in the frontal cortex and the striatum and to a lesser extent in the hippocampus of rats.
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更新时间:2024/1/2 10:16:09
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