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Paroxetine hydrochloride hemihydrate

CAS No. : 110429-35-1

MCE 站：Paroxetine hydrochloride hemihydrate

产品活性：Paroxetine hydrochloride hemihydrate 是一种抗抑郁药，为高效的五羟色胺再摄取抑制剂，能抑制 GRK2 活性，IC₅₀ 值为 14?μM。

研究领域：Neuronal Signaling  |  Autophagy

作用靶点：Serotonin Transporter  |  Autophagy

In Vitro: Paroxetine (1?μM and 10?μM) distinctly restrains T cell migration induced by CX3CL1 through inhibiting GRK2. Paroxetine inhibits GRK2 induced activation of ERK. Paroxetine (10 μM) reduces pro-inflammatory cytokines in LPS-stimulated BV2 cells. Paroxetine (0-5 μM) leads to a dose-dependent inhibition on LPS-induced production of TNF-α and IL-1β in BV2 cells. Paroxetine also inhibits lipopolysaccharide (LPS)-induced nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in BV2 cells. Paroxetine (5 μM) blocks LPS-induced JNK activation and attenuates baseline ERK1/2 activity in BV2 cells. Paroxetine relieves microglia-mediated neurotoxicity, and suppresses LPS-stimulated pro-inflammatory cytokines and NO in primary microglial cells.

In Vivo: Paroxetine treatment obviously attenuates the symptoms of CIA rats. Paroxetine treatment clearly prevents the histological damage of joints and alleviates T cells infiltration into synovial tissue. Paroxetine reveals a strong effect on inhibiting CX3CL1 production in synovial tissues. Paroxetine (20 mg/kg/day) reduces the myocyte cross-sectional area in rat and ROS formation in the remote myocardium. Paroxetine reduces the susceptibility to ventricular tachycardia. Paroxetine treatment following MI decreases LV remodeling and susceptibility to arrhythmias, probably by reducing ROS formation. In CCI paroxetine-treated group, paroxetine (10 mg/kg, i.p.) produces hyperalgesia at days 7 and 10 (P<0.01), but a decrease in pain behavior is seen at day 14. Moreover, paroxetine (10 mg/kg) significantly attenuates tactile hypersensitivity when compared to CCI vehicle-treated group.

相关产品：Paroxetine hydrochloride  |  Fluvoxamine maleate  |  Imipramine hydrochloride  |  Sertraline hydrochloride  |  Desipramine hydrochloride  |  Duloxetine hydrochloride  |  Amitriptyline hydrochloride  |  Escitalopram oxalate  |  Clomipramine hydrochloride  |  Citalopram hydrobromide  |  Vilazodone  |  Dapoxetine hydrochloride  |  Venlafaxine hydrochloride  |  Milnacipran hydrochloride  |  Amitifadine hydrochloride  |  Azaphen dihydrochloride monohydrate  |  Cinchonidine  |  (S)-Venlafaxine

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