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Ciprofibrate

CAS No. : 52214-84-3

MCE 站：Ciprofibrate

产品活性：Ciprofibrate (Win35833) 是一种有效的过氧化物酶体 (peroxisome proliferator) 增殖物，可增加 PPARalpha 的磷酸化水平。Ciprofibrate 是一种有口服活性降血脂试剂，可用于原发性高脂血症的研究。

研究领域：Cell Cycle/DNA Damage

作用靶点：PPAR

In Vitro: Ciprofibrate (500 μM; 4 hours) increases the PPARa phosphorylation level in rat Fao cells.
In a LucLite assay, Ciprofibrate (10-100μM; 24 hours) induces PPARR activation by existing increased LUC activities in the rat liver H4IIEC3 cells transfected with PPRE-AB LUC reporter gene plasmid.
Ciprofibrate (10-100 μM; 24 hours) is not cytotoxic for HepG2 cells, and the cell viability is 99.7%.
Ciprofibrate (100 μM; 24 hours) also abolishes FFAs mixture-induced lipid deposition and decreases FFAs mixture-increased TG contents?in HepG2 cells.
Ciprofibrate (100 μM; 24 hours) almost entirely eliminates the FFAs mixture-induced inflammatory cytokines overproduction, including MCP-1, TNF-α, and IL-6 in HepG2 cells.

In Vivo: Ciprofibrate (oral administration; 10 mg/kg/day; 3 days) does not result in any significant effects on body weight or absolute liver weight for MCD diet-fed mice. Ciprofibrate improves hepatic steatosis and reduced hepatic necro-inflammation in MCD diet-fed mice. It also reduced hepatic cytokine protein and mRNA levels (MCP-1, TNFα and IL-6) as compared to those of ?choline-deficient (MCD) diet-fed mice.

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