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Itopride hydrochloride

CAS No. : 122892-31-3

MCE 站：Itopride hydrochloride

产品活性：Itopride hydrochloride (HSR803) 是一种促胃动力的 Benzamide (HY-Z0283) 衍生物。Itopride hydrochloride 是一种乙酰胆碱酯酶 (AChE) 和多巴胺受体 D2 (D2DR) 抑制剂。

研究领域：Neuronal Signaling  |  GPCR/G Protein

作用靶点：AChE  |  Dopamine Receptor

In Vitro: Itopride hydrochloride has prokinetic effects on both the ileum and colon, which are regulated through inhibitory effects on AChE and antagonistic effects on dopamine D2 receptor.
Itopride hydrochloride (0.1 nM-1 μM) significantly accelerats the propagation velocity of the peristalsis in ex guinea pig ileum.

In Vivo: Itopride hydrochloride (30 mg/kg; p.o.) significantly accelerates gastric emptying compared with the vehicle group.
Itopride hydrochloride (30 mg/kg; p.o.) displays C_max of 358 ‰, T_1/2 of 24.9 min.

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