型号:
产品价格:电议      采购度:1602      原产地:美洲
发布时间:2021/7/27 1:39:56 所属地区:上海 上海市
简要描述:
IWR-1是端锚聚合酶抑制剂,抑制Wnt/β-catenin信号传导途径。
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CAS No. : 1127442-82-3
MCE 站:IWR-1
产品活性:IWR-1是端锚聚合酶抑制剂,抑制Wnt/β-catenin信号传导途径。
研究领域:Stem Cell/Wnt
作用靶点:Wnt
In Vitro: Both IWR-1 and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects in vitro. IWR-1 exerts its effect via interaction with Axin, while XAV939 binds TNKS directly. IWR-1 (10 μM) induces stabilization of β-catenin disruption complex. IWR-1 (10 μM) is added to the medium together with MIF, the size of cell colonies is extremely decreased, and that indicates the promoting effect of MIF on NSPC proliferation is inhibited by IWR-1 in any MIF concentration group. 2, 5 and 10 μM of IWR-1 significantly inhibits the proliferation of NSPC dose-dependently. IWR-1 inhibites the promoting effect of MIF on NSPC differentiation to neuron lineage. IWR-1 treatment in the presence of maximal stimulatory dose of FSH (0.5 ng/mL) results in a dose dependent inhibition of the stimulatory effect of FSH with > 75% inhibition observed at the maximal inhibitory dose of IWR-1 (1 ?M). IWR-1 treatment partially reverses the FSH-induced inhibition of granulosa cell CARTPT mRNA expression.
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更新时间:2024/1/2 10:16:09
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