型号:
产品价格:电议      采购度:1597      原产地:美洲
发布时间:2021/7/27 1:41:09 所属地区:上海 上海市
简要描述:
CHIR-98014 是一种有效的,细胞通透的 GSK-3 抑制剂,可抑制 GSK-3α 和 GSK-3β 的活性,IC50 值分别为 和 nM;CHIR-98014 对 cdc2 和 erk2 的作用较弱。
标签:chir
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CAS No. : 252935-94-7
MCE 站:CHIR-98014
产品活性:CHIR-98014 是一种有效的,细胞通透的 GSK-3 抑制剂,可抑制 GSK-3α 和 GSK-3β 的活性,IC50 值分别为 0.65 和 0.58 nM;CHIR-98014 对 cdc2 和 erk2 的作用较弱。
研究领域:PI3K/Akt/mTOR | Stem Cell/Wnt
作用靶点:GSK-3
In Vitro: CHIR 98014 inhibits human GSK-3β with Ki value of 0.87 nM. CHIR 98014 causes GS stimulation in CHO-IR cells and rat hepatocytes, with EC50s of 106 nM and 107 nM, respectively. CHIR-98014 (1 μM) reduces the viability of ES-CCE cells by 52%, with IC50 of 1.1 μM. Moreover, CHIR-98014 in combination with CHIR-99021 results in a significant activation of the Wnt/beta-catenin pathway in ES-D3 cells. In CHIR-98014 treated cells, the T gene expression is induced up to 2,500-fold. CHIR-98014 (1 μM) also yields around 50% Brachyury-positive cells, with EC50 of 0.32 μM. CHIR98014 (10 μM) prevents loss of neurites caused by 20 μM PrP1-30 in cortical and hippocampal neurons, and substantially decreases the amount of dead cells.
In Vivo: CHIR 98014 (30 mg/kg, i.p.) exhibits a significant reduction in fasting hyperglycemia within 4 h of treatment and shows improved glucose disposal during an ipGTT in markedly diabetic and insulin-resistant db/db mice.
相关产品:Bioactive Compound Library Plus | Kinase Inhibitor Library | PI3K/Akt/mTOR Compound Library | Stem Cell Signaling Compound Library | Wnt/Hedgehog/Notch Compound Library | Anti-Aging Compound Library | Reprogramming Compound Library | Diabetes Related Compound Library | Oxygen Sensing Compound Library | Glycolysis Compound Library | Cytoskeleton Compound Library | Anti-Pancreatic Cancer Compound Library | CHIR-99021 | SB 216763 | AR-A014418 | TDZD-8 | Kenpaullone | GSK 3 Inhibitor IX | Cromolyn sodium | R547 | SB 415286 | IM-12 | Indirubin-3'-monoxime | 1-Azakenpaullone | AZD2858 | BIO-acetoxime | CP21R7 | Bikinin | GNF4877 | GSK-3β inhibitor 1 | hSMG-1 inhibitor 11j | TCS 21311 | BIP-135 | 5-Iodo-indirubin-3'-monoxime | Alsterpaullone | GSK-3 inhibitor 1 | GSK-3β inhibitor 2 | Manzamine A hydrochloride | 2B-(SP)
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更新时间:2024/1/2 10:16:09
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