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Sevelamer carbonate

CAS No. : 845273-93-0

MCE 站：Sevelamer carbonate

产品活性：Sevelamer carbonate 是一种具有口服活性的非钙基磷酸盐结合剂 (phosphate binding agent)，用于慢性肾脏病 (CKD) 的高磷血症研究。Sevelamer carbonate 能有效降低体内血清磷水平，但对体内血清钙、氯水平影响极小。Sevelamer carbonate 被认为是七氟乙烯 (HY-13995) 的一种改进的缓冲形式。

研究领域：Others

作用靶点：Others

In Vivo: Sevelamer carbonate is an anion-exchange resin with the same polymeric structure as that of sevelamer hydrochloride, but with carbonate replacing chloride as the anion.
Sevelamer carbonate lowers serum phosphorus levels and calcium-phosphorus product to a similar extent as sevelamer hydrochloride. Additionally, Sevelamer carbonate is associated with significant effects on decreasing low-density lipoprotein cholesterol levels and may cause less metabolic acidosis than sevelamer hydrochloride in vivo.
Sevelamer carbonate (oral adminstration; 1% mixed in diet; 2-3 weeks) significantly reduces serum phosphate level in Npt2b-deficient mice. Npt2b attenuates the hyperphosphatemia in control animals and that sevelamer carbonate treatment has an additional benefit in maintaining serum phosphate in the normal range.
Sevelamer carbonate (oral adminstration; ?1% mixed in diet; 2-3 weeks) does not alter serum phosphate levels in uremic WT mice (10.04 mg/dl , untreated versus 9.67mg/dl , binder-treated mg/dl) but further decreased serum phosphate levels in uremic Npt2b?/??mice in uremic mouse model.

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