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产品价格:电议      采购度:1616      原产地:美洲
发布时间:2021/7/27 3:11:22 所属地区:上海 上海市
简要描述:
SC-43,Sorafenib 的衍生物,是一种有效的具有口服活性的 SHP-1 (PTPN6) 激动剂。SC-43 可抑制 STAT3 的磷酸化并诱导细胞凋亡 (apoptosis),具有抗纤维化和抗癌作用。
标签:sc
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CAS No. : 1400989-25-4
MCE 站:SC-43
产品活性:SC-43,Sorafenib 的衍生物,是一种有效的具有口服活性的 SHP-1 (PTPN6) 激动剂。SC-43 可抑制 STAT3 的磷酸化并诱导细胞凋亡 (apoptosis),具有抗纤维化和抗癌作用。
研究领域:Metabolic Enzyme/Protease | JAK/STAT Signaling | Stem Cell/Wnt | Apoptosis
作用靶点:Phosphatase | STAT | Apoptosis
In Vitro: SC-43 (0-10 μM; 24-72 hours; HuCCT-1, KKU-100, and CGCCA cells) treatment reveals the anti-proliferative effects in cholangiocarcinoma (CCA) cell lines in a dose-dependent manner after treating 24, 48 and 72 hours respectively.
SC-43 (0-10 μM; 24 hours; HuCCT-1, KKU-100, and CGCCA cells) treatment shows increased sub-G1 cells and G2-M arrest, indicating SC-43 induced differential apoptotic effects in these cell lines.
SC-43 (0-10 μM; 24 hours; HuCCT-1, KKU-100, and CGCCA cells) treatment demonstrates significant increase in cleaved caspase-3 and PARP level.
SC-43 activates SH2 domain-containing phosphatase 1 (SHP-1) activity, leading to p-STAT3 and downstream cyclin B1 and Cdc2 downregulation. SC-43 augments SHP-1 activity by direct binding to N-SH2 and relief of its autoinhibition.
In Vivo: SC-43 (10-30 mg/kg; oral gavage; daily; for 23 days; male NCr athymic nude mice) treatment exhibits xenograft tumor growth inhibition, p-STAT3 reduction and SHP-1 activity elevation.
相关产品:Bioactive Compound Library Plus | Apoptosis Compound Library | Immunology/Inflammation Compound Library | JAK/STAT Compound Library | Kinase Inhibitor Library | Metabolism/Protease Compound Library | Stem Cell Signaling Compound Library | Anti-Cancer Compound Library | Small Molecule Immuno-Oncology Compound Library | Anti-Aging Compound Library | Differentiation Inducing Compound Library | Orally Active Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Phosphatase Inhibitor Library | MG-132 | LY294002 | Doxorubicin hydrochloride | Bafilomycin A1 | Paclitaxel | Y-27632 dihydrochloride | Acetylcysteine | Angiotensin II human | SP600125 | 5-Fluorouracil | Staurosporine | Bortezomib | Tamoxifen | 2-Deoxy-D-glucose | Gemcitabine | Verteporfin | Decitabine | Actinomycin D | Temozolomide | Cyclosporin A | BAY 11-7082 | Etoposide | Mitomycin C | CCCP | DAPT | Rotenone | Etomoxir | Stattic | Docetaxel
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更新时间:2024/1/2 10:16:26
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