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5-Carboxamidotryptamine maleate

CAS No. : 74885-72-6

MCE 站：5-Carboxamidotryptamine maleate

产品活性：5-Carboxamidotryptamine maleate (5-CT maleate) 是一种有效的 5-HT_1A，5-HT_1B，5-HT_1D，5-HT₅ 和 5-HT₇ 受体激动剂。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：5-HT Receptor

In Vitro: [³H]-5-Carboxamidotryptamine (5-CT) binding to 5-HT_1D sites in bovine substantia nigra is rapid, reversible and saturable, displaying high affinity (K_d = 0.38 nM) and low non-specific binding.
In bovine substantia nigra, [³H]-5-Carboxamidotryptamine (5-CT) labelled an equivalent number of binding sites to [³H]-5-Carboxamidotryptamine (403 and 362 fmol/mg protein, respectively) and binding is sensitive to guanine nucleotides.

In Vivo: Topical 5-Carboxamidotryptamine (0.01-1000 μM) to the exposed dura mater encephala produced decreases in diastolic blood pressure, variable changes in meningeal blood flow and increases in conductance (i.e. dilatation) in the middle meningeal artery of anesthetized Wistar rats (serotonin depletion and treated with 20 mg/kg corticosterone).

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