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Carboxy-PTIO potassium

CAS No. : 148819-94-7

MCE 站：Carboxy-PTIO potassium

产品活性：Carboxy-PTIO potassium 是一种有效的一氧化氮 (NO) 清除剂，能与 NO 快速反应产生 NO₂。Carboxy-PTIO potassium 通过对脂多糖诱导大鼠模型中 NO 的直接清除作用，可预防低血压和内毒素休克。

研究领域：Immunology/Inflammation

作用靶点：NO Synthase

In Vitro: Carboxy-PTIO potassium (200 μM; 1 h prior to physalin A; 24 hours) significantly suppresses the stimulation of NO expression induced by physalin A treatment, but no change is observed in Carboxy-PTIO treatment alone.
Carboxy-PTIO potassium (200 μM; 1 h prior to physalin A; 24 hours) reduces physalin A-induced cleavage of procaspase-3 and PARP, down-regulated ICAD expression,diminishing DNA fragmentation in nuclei.
Carboxy-PTIO potassium (200 μM; 1 h prior to physalin A; 24 hours) shows no effect on iNOS expression. However, decreased-mTOR and p-mTOR levels induced by physalin A is reversed by Carboxy-PTIO with concomitant suppression of LC3 I to LC3 II conversions in A375-S2 cells .

In Vivo: Carboxy-PTIO (intravenous?injection; 0.056-1.70 mg/kg/min; infused for 1 hr beginning 90 min after the LPS injection 90 min) treatment improves the hypotension, renal dysfunction and survival rate in Lps-treated rats. But it does not affect each parameter in naomal rats.

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