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Minoxidil sulfate

CAS No. : 83701-22-8

MCE 站：Minoxidil sulfate

产品活性：Minoxidil sulfate 是一种有效的 ATP 敏感的 K⁺ 通道 (K⁺ channel) 激动剂，是米诺地尔的硫酸代谢物。Minoxidil sulfate 被认为是一种血管扩张试剂，在动物实验模型中，促进头发生长。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Potassium Channel

In Vitro: Minoxidil sulfate (1-100 μM; 2 hours) significantly reduces the permeability of bloode-brain tumor barrier (BTB) in a monolayer of RBMEC in a time-dependent manner, additionally,the effects of MS on transendothelial electrical resistance (TEER) is Transendothelial electrical resistance (TEER) at 2 h with high concentration.
Minoxidil sulfate (0-100 μM; 0-4 hours) increases the RhoA activation in brain tumor tissue by 1 h and the highest level appears at 2 h, it also significantly induces transient PKB phosphorylation at Ser-473, without affecting total PKB levels. Addiotionally, LY294002 partly prevents the phosphorylation of PKB induced by MS.

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