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Tolmetin

CAS No. : 26171-23-3

MCE 站：Tolmetin

产品活性：Tolmetin 是一种具有口服活性的，有效的 COX 抑制剂，对人 COX-1 和 COX-2 的 IC₅₀ 值分别为 0.35 ?M 和 0.82 ?M。Tolmetin 属于非甾体类物质，具有强效的抗炎活性。

研究领域：Immunology/Inflammation

作用靶点：COX

In Vitro: Tolmetin (0.25 mM) does not attenuate lipid peroxidation in rat brain homogenate. Tolmetin (0.25, 0.5, 0.75, 1 mM) shows radical scavenging properties but without superoxide anion generation in rat brain homogenat.
Tolmetin (0.001-100 μM) shows anticancer activity againts HT-29 colon cancer cell line in a dose-dependent manner.
Tolmetin (0-100 μM) shows no effect on osteoblast growth.

In Vivo: Tolmetin (30,100 mg/kg; gavage; single dose or twice daily for 3 and 14 days) shows maximal ulcerogenic effect 4 h after the single dose, while potently decreases after 3 and 14 days of repeated administration in male Wistar rats weighing 180-200 g. Tolmetin causes gastric lesions in 100 mg/kg.
Tolmetin (5 mg/kg twice a day for 5 days) pre-treatment considerably attenuates quinolinic acid (QA)-induced neurotoxicity.

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