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Tetraethylammonium chloride

CAS No. : 56-34-8

MCE 站：Tetraethylammonium chloride

产品活性：Tetraethylammonium chloride 是一种非选择性的钾通道 (potassium channel) 阻滞剂。Tetraethylammonium chloride 是有机阳离子转运蛋白的良好底物，并具有抗肿瘤特性。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Potassium Channel

In Vitro: Tetraethylammonium (0.2-60 mM; 24-72 hours; C6 and 9L glioma cells) treatment inhibits the proliferation of C6 and 9L cells in a dose- and time-dependent manner.
Tetraethylammonium (40 mM; 24-72 hours; C6 and 9L glioma cells) treatment significantly increases apoptosis in cells.
Tetraethylammonium (40 mM; 12-48 hours; C6 and 9L glioma cells) treatment significantly elevates Bax/Bcl-2 protein ratio in a time-dependent manner.
The generation of intracellular ROS increased in C6 and 9L cells by the addition of 20 and 40 mM Tetraethylammonium.

In Vivo: Tetraethylammonium (1 mM, 3 mM, and 5 mM) significantly increases the amplitude and frequency of contractility of colon and rectum from rats in longitudinal and circular direction. Tetraethylammonium at 5 mM and 15 mM concentrations shows no effect on histology of colon and rectum from rats that are administered locally with Tetraethylammonium into colon lumen from anus for 10 days.

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