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Propiverine hydrochloride

CAS No. : 54556-98-8

MCE 站：Propiverine hydrochloride

产品活性：Propiverine hydrochloride 是具有钙拮抗和抗胆碱能特性的膀胱痉挛剂。Propiverine hydrochloride 可用于研究膀胱过度活动和尿失禁。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Membrane Transporter/Ion Channel

作用靶点：mAChR  |  Calcium Channel

In Vitro: Propiverine (10-3000 nM) inhibits the speci?c binding of [³H]NMS, with K_is of 339, 193 and 497 nM in the bladder, submaxillary gland and heart of mice respectively.

In Vivo: Propiverine (0.5 mg/day; p.o. once daily for 2 weeks) significantly increases UBP and LPP during passive intravesical pressure elevation, and also increases plasma norepinephrine and epinephrine levelsin rats.
Propiverine (0.01-1 mg/kg; i.v.) decreases the UBP and totally suppresses the sneeze reflex at the dose of 1 mg/kg in vivo.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Membrane Transporter/Ion Channel Compound Library  |  Neuronal Signaling Compound Library  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  NMPA-Approved Drug Library  |  Orally Active Compound Library  |  Neurotransmitter Receptor Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Neuroprotective Compound Library  |  Clozapine N-oxide  |  Ionomycin  |  Deschloroclozapine  |  L-Ascorbic acid  |  Thapsigargin  |  Verapamil hydrochloride  |  Ebselen  |  Pilocarpine Hydrochloride  |  Nifedipine  |  Fasudil Hydrochloride  |  2-Aminoethyl diphenylborinate  |  Acetylcholine chloride  |  GSK1016790A  |  Atropine  |  Tetrandrine  |  Mibefradil dihydrochloride  |  CDN1163  |  Olanzapine  |  Nimodipine  |  Gabapentin  |  L-Phenylalanine  |  Penfluridol  |  Diltiazem hydrochloride  |  Istaroxime hydrochloride  |  Cromolyn sodium  |  GSK-7975A  |  (S)-(-)-Bay-K-8644

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