MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

1,4-DPCA

CAS No. : 331830-20-7

MCE 站：1,4-DPCA

产品活性：1,4-DPCA，一种有效的选择性脯氨酰-4-羟化酶 (prolyl-4-hydroxylase) 抑制剂，也是人包皮成纤维细胞中的胶原蛋白羟基化抑制剂，IC₅₀ 为 2.4 ?M。1,4-DPCA 抑制脯氨酰-4-羟化酶 α 同工型，可稳定 HIF-1α 蛋白。1,4-DPCA 还抑制 FIH，IC₅₀ 为 60 μM。

研究领域：Metabolic Enzyme/Protease

作用靶点：HIF/HIF Prolyl-Hydroxylase

In Vitro: 1,4-DPCA (24 hours) treatment specifically increases the expression of multiple target genes, including the proangiogenic target genes Vegfa and Hmox1 and proglycolytic targets Ldh-a, Pgk1, Pdk1, and Glut1 in mouse B6 cells.
1,4-DPCA treatment significantly reduces the colony sizes of T4-2 (10 μM 1,4-DPCA) and ZR-75-1 cells (20 μM 1,4-DPCA). 1,4-DPCA-treated T4-2 cells form polarized spheroids in 3D culture. 1,4-DPCA treatment significantly reduces invasive branches in DA-MB-157 (20 μM 1,4-DPCA) and MDA-MB-231 (10 μM 1,4-DPCA) cells.1,4-DPCA inhibits the proliferation of T4-2, ZR-75-1, MDA-MB-157 and MDA-MB-231 cells.

In Vivo: 1,4-DPCA treatment suppresses connective tissue ingrowth in porous porous poly (lactic-co-glycolic acid) (PLGA) discs implanted in the peritoneal cavity for 28 days in mice. 1,4-DPCA is found to be effective at inhibiting collagen deposition within and on the outer surface of the disc, and also limited connective tissue ingrowth, but not to the extent of glucocorticoid inhibition.

相关产品：Bioactive Compound Library Plus  |  Epigenetics Compound Library  |  Immunology/Inflammation Compound Library  |  Metabolism/Protease Compound Library  |  Anti-Cancer Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Glutamine Metabolism Compound Library  |  Anti-Breast Cancer Compound Library  |  DMOG  |  PX-478  |  Oltipraz  |  Amifostine  |  Chlorogenic acid  |  IOX2  |  ML228  |  Acriflavine  |  IOX4  |  FG-2216  |  Fraxinellone  |  AKBA  |  Oroxylin A  |  Tilorone dihydrochloride  |  Glucosamine  |  SYP-5  |  Hydralazine hydrochloride  |  M1001  |  Echinomycin  |  GN44028  |  Hydroxycitric acid tripotassium hydrate  |  EL-102  |  Deoxyshikonin  |  THS-044  |  Dencichine  |  Gramicidin A  |  Verucopeptin  |  1,4-DPCA ethyl ester  |  ENMD-1198

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。