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SP-96

CAS No. :

MCE 站：SP-96

产品活性：SP-96 是一种高效、选择性和 ATP 竞争性 Aurora B?抑制剂，IC₅₀ 为 0.316 nM，对 FLT3 和 KIT 具有 >2000 倍选择性。SP-96 在 NCI60 筛选中表现出选择性生长抑制，对 MDA-MD-468 等乳腺癌细胞具有选择性 (GI₅₀=107 nM)。SP-96 可用于三阴性乳腺癌 (TNBC) 的相关研究。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics

作用靶点：Aurora Kinase

In Vitro: SP-96 is a?highly potent, selective and non-ATP-competitive Aurora B (IC₅₀=0.316 nM) inhibitor and shows >2000 fold selectivity against FLT3 (IC₅₀=1475.6 nM) and KIT (IC₅₀=1307.6 nM).
SP-96 (0-1 ?M; 24 hours) is not promiscuous, rather selective for a few cell lines, it inhibits MDA-MB-468, CCRF-CEM, COLO 205 and A498 cell growth with GI₅₀ values of 107 nM,47.4 nM, 50.3 nM and 53.2 nM, respectively.
SP-96 (63.2 nM) inhibits Aurora B activity in H460 cells by the characteristics of increased DNA content, and it increases cell volume with enormous nucleus.
SP-96 (0-2 ?M) inhibits Aurora B enzymatic activity with an IC₅₀ of 0.316 nM and inhibits Aurora A with observed IC₅₀ value of 18.975 nM. SP-96 shows >2000 fold selectivity against FLT3 (IC₅₀=1475.6 nM) and KIT (IC₅₀=1307.6 nM). Meanwhile, it exhibits inhibitory effects on other receptor tyrosine kinases (RTKs) namely EGFR, RET and HER2 with IC₅₀ value ≥2 ?M.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Epigenetics Compound Library  |  Kinase Inhibitor Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Cytoskeleton Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  AT9283  |  KW-2449  |  PF-03814735  |  ZM-447439  |  SNS-314 mesylate  |  CCT 137690  |  SCH-1473759 hydrochloride  |  NU6140  |  Aurora kinase inhibitor-2  |  Tripolin A  |  Aurora B inhibitor 1  |  Aurora inhibitor 1

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