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RSVA405

CAS No. : 140405-36-3

MCE 站：RSVA405

产品活性：RSVA405 是一种有效和具有口服活性的 AMPK 激活剂，EC₅₀ 值为 1 μM。RSVA405 通过促进 CaMKKβ 依赖的 AMPK 活化，从而抑制 mTOR，并促进自噬 (autophagy) 以增加 Aβ 的降解。RSVA405 通过抑制 STAT3 功能具有抗炎作用。RSVA405 也可用于肥胖症的研究。

研究领域：Epigenetics  |  PI3K/Akt/mTOR  |  JAK/STAT Signaling  |  Stem Cell/Wnt  |  Autophagy

作用靶点：AMPK  |  STAT  |  Autophagy

In Vitro: RSVA405 (0.2-2 μM; 24 h) inhibits adipocyte differentiation.
RSVA405 (0.2-2 μM; 24 h) significantly inhibits the expression of peroxisome proliferator-activated receptor (PPAR)-γ, fatty acid synthase (FAS) and fatty acid binding protein 4 (aP2) in 3T3-L1 cells.
RSVA405 (1-3 μM; 16 h) inhibits LPS-induced STAT3 activity, intracellular signaling, and cytokine response in activated RAW 264.7 macrophages.
RSVA405 (1-3 μM; 24 h) inhibits mTOR, induces autophagy, and facilitates the lysosomal degradation of Aβ, with an EC₅₀ of ?1 μM in APP-HEK293 cells.

In Vivo: RSVA405 (3 mg/kg; i.p.) attenuates renal injury and protects renal function after ischemia-reperfusion (I/R) in rats.
RSVA405 (20-100 mg/kg/d; p.o. for 11 weeks) significantly reduces the body weight gain of mice fed a high-fat diet.

相关产品：Bioactive Compound Library Plus  |  Epigenetics Compound Library  |  Immunology/Inflammation Compound Library  |  JAK/STAT Compound Library  |  Kinase Inhibitor Library  |  PI3K/Akt/mTOR Compound Library  |  Stem Cell Signaling Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Differentiation Inducing Compound Library  |  Oxygen Sensing Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Orally Active Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Doxorubicin hydrochloride  |  Metformin hydrochloride  |  Dorsomorphin  |  AICAR  |  Stattic  |  AG490  |  A-769662  |  Fludarabine  |  AS1517499  |  Niclosamide  |  Artesunate  |  GSK-690693  |  Homoharringtonine  |  STO-609  |  TPCA-1  |  Colivelin TFA  |  Cryptotanshinone  |  Napabucasin  |  Pimozide  |  STAT5-IN-1  |  C188-9  |  Phenformin hydrochloride  |  [6]-Gingerol  |  Scutellarin  |  WZ4003  |  BP-1-102  |  Cucurbitacin I

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