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COH-SR4

CAS No. : 73439-19-7

MCE 站：COH-SR4

产品活性：COH-SR4 是一种 AMPK 活化剂。COH-SR4 对白血病、黑色素瘤、乳腺癌和肺癌显示出强大的抗增殖活性。COH-SR4 通过激活 AMPK 来抑制脂肪细胞分化，有望用于肥胖及代谢紊乱相关的研究。

研究领域：Epigenetics  |  PI3K/Akt/mTOR

作用靶点：AMPK

In Vitro: COH-SR4 (1-5 μM; 24 hours) results in a dose-dependent increase in the phosphorylation of AMPK and its substrate ACC in 3T3-L1 preadipocytes, as well as in cancer cells such as HL-60, HeLa, MCF-7.
COH-SR4 (3-5 ?M; 7 days) significantly inhibits 3T3-L1 adipocyte differentiation in a dose-dependent manner.
COH-SR4 (1-5 μM; 24 hours) promotes cell G1 cycle arrest.
COH-SR4 significantly reduces intracellular lipid accumulation and downregulates the expression of key adipogenesis-related transcription factors and lipogenic proteins.

In Vivo: COH-SR4 (5 mg/kg; i.g.; 3x/week; for 6 weeks) reduces body weight and fat mass in high fat diet (HFD) obese mice without affecting food intake.
COH-SR4 improves glycemic control and dyslipidemia in HFD obese mice.
COH-SR4 decreases adipose tissue hypertrophy and affects circulating adipokine levels in HFD obese mice.
COH-SR4 prevents hepatic lipid accumulation and fatty liver in HFD obese mice.

相关产品：Bioactive Compound Library Plus  |  Epigenetics Compound Library  |  Kinase Inhibitor Library  |  PI3K/Akt/mTOR Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Oxygen Sensing Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Doxorubicin hydrochloride  |  Metformin hydrochloride  |  Dorsomorphin  |  AICAR  |  A-769662  |  GSK-690693  |  STO-609  |  Phenformin hydrochloride  |  [6]-Gingerol  |  WZ4003  |  Palmitelaidic Acid  |  Urolithin B  |  GSK621  |  Flufenamic acid  |  Chitosan oligosaccharide  |  Amarogentin  |  7-Methoxyisoflavone  |  Buformin hydrochloride  |  Danthron  |  Ginkgolide C  |  ZLN024 hydrochloride  |  Ampkinone  |  EB-3D  |  Demethyleneberberine  |  Gomisin J  |  Platycodin D  |  Methyl cinnamate

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