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Tetrahydroxyquinone monohydrate

CAS No. : 1215458-51-7

MCE 站：Tetrahydroxyquinone monohydrate

产品活性：Tetrahydroxyquinone monohydrate (Tetrahydroxy-1,4-benzoquinone monohydrate)，一种抗白内障剂，是一种具有氧化还原活性的苯醌。Tetrahydroxyquinone monohydrate 可与半醌自由基一起参与氧化还原循环，导致活性氧 (ROS) 形成。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Reactive Oxygen Species  |  Apoptosis

In Vitro: Tetrahydroxyquinone (100-500 μM; 24 hours; HL60 cells) treatment shows cytotoxic for HL60 leukaemia cells by total protein content (IC₅₀ of 20 ?M), phosphatase activity (IC₅₀ of 40 ?M), or by MTT assay (IC₅₀ of 45 ?M). Tetrahydroxyquinone is an efficient inducer of ROS production in HL60 leukaemia cells.
Tetrahydroxyquinone efficiently activates caspase 3 in concentration in excess of 25 ?M, stimulates DNA fragmentation at the same concentration and provoke phosphatidylserine exposure.
Tetrahydroxyquinone induces the release of cytochrome c from the mitochondria at concentration as low as 25 ?M. Tetrahydroxyquinone treatment also causes increase of phosphorylation of Ser473 in protein kinase B (the Bad kinase for Ser112).

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