MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

VU041

CAS No. : 332943-64-3

MCE 站：VU041

产品活性：VU041 是个亚微摩尔亲和力 Anopheles (An.) gambiae 和 Aedes (Ae.) aegypti Kir1 通道的抑制剂，IC₅₀ 值分别为 2.5 μM 和 1.7 μM。VU041 明显抑制哺乳动物 Kir2.1 通道 (IC₅₀ 为12.7 μM)，对哺乳动物 Kir1.1，Kir4.1，Kir6.2/SUR1 和 Kir7.1 的抑制作用较小。VU041 也可导致 Malpighian 小管功能受损。

研究领域：Membrane Transporter/Ion Channel  |  Anti-infection

作用靶点：Potassium Channel  |  Parasite

In Vitro: VU041 is only moderately metabolized by cytochrome P450 enzymes and does not appear to be metabolized by esterases. VU041 is the first small-molecule inhibitor of mosquito Kir1 channels that exhibits topical toxicity in both insecticide-susceptible and -resistant lines of mosquitoes.

In Vivo: Topical VU041 application to adult female mosquitoes of both species inhibits their fecundity. Importantly, VU041 is selective for mosquito Kir channels over mammalian Kir channel orthologs and non-lethal to adult honey bees (Apis mellifera). The in vivo experiments of blood meal processing and diuretic capacity suggest that one mechanism of action of VU041 is the disruption of excretory functions mediated by Malpighian tubules.

相关产品：Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Membrane Transporter/Ion Channel Compound Library  |  Chloroquine  |  Nigericin sodium salt  |  Hydroxychloroquine sulfate  |  BAPTA-AM  |  Ivermectin  |  Kaempferol  |  Metronidazole  |  Dihydroartemisinin  |  Niclosamide  |  Suramin sodium salt  |  Artesunate  |  Rosuvastatin Calcium  |  SKF-96365 hydrochloride  |  Glibenclamide  |  Artemisinin  |  SCH-23390 hydrochloride  |  Quinidine  |  Tetrandrine  |  Halofuginone  |  Miransertib  |  Amiodarone hydrochloride  |  TRAM-34  |  Ifenprodil tartrate  |  Mefloquine hydrochloride  |  Quinacrine dihydrochloride  |  Sanguinarine chloride  |  Amodiaquine dihydrochloride dihydrate  |  Minoxidil  |  Ascomycin

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。