型号:
产品价格:电议      采购度:1597      原产地:美洲
发布时间:2021/7/27 9:45:00 所属地区:上海 上海市
简要描述:
S-Methylisothiourea sulfate 是一种高效的,选择性的,竞争性的诱导型一氧化氮合酶 (iNOS) 抑制剂。S-Methylisothiourea sulfate 在感染性休克的啮齿动物模型中发挥有益作用。
产品详情
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 867-44-7
MCE 站:S-Methylisothiourea sulfate
产品活性:S-Methylisothiourea sulfate 是一种高效的,选择性的,竞争性的诱导型一氧化氮合酶 (iNOS) 抑制剂。S-Methylisothiourea sulfate 在感染性休克的啮齿动物模型中发挥有益作用。
研究领域:Immunology/Inflammation | Anti-infection
作用靶点:NO Synthase | HSV
In Vitro: S-Methylisothiourea sulfate is a competitive inhibitor of iNOS activity at the L-arginine site.
S-Methylisothiourea sulfate prevents the NO-mediated cytotoxic effect of LPS in cultured macrophages.
S-Methylisothiourea sulfate (100 nM-100 μM) exhibits inhibitory effects on LPS (ug/mL)-induced nitrite production in J774.2 macrophages and rat aortic vascular smooth muscle cells.
S-Methylisothiourea sulfate (up to 1 mM) does not inhibit the activity of xanthine oxidase, diaphorase, lactate dehydrogenase, monoamine oxidase, catalase, cytochrome P450, or superoxide dismutase.
In Vivo: S-Methylisothiourea sulfate (0.01-3 mg/kg; i.v.) dose-dependently reverses the hypotension and the vascular hyporeactivity to vasoconstrictor agents caused by endotoxin LPS in anesthetized rats.
S-Methylisothiourea sulfate (5 mg/kg; i.p.; given 2 hr after LPS; 10 mg/kg; i.p.) attenuates the rises in plasma alanine and aspartate aminotransferases, bilirubin, and creatinine and also prevents hypocalcaemia when measured 6 hr after administration of LPS.
S-Methylisothiourea sulfate (1 mg/kg; i.p.) improves 24-hr survival of mice treated with a high dose of LPS (60 mg/kg; i.p.).
相关产品:Bioactive Compound Library Plus | Anti-Infection Compound Library | Immunology/Inflammation Compound Library | Antiviral Compound Library | Anti-Aging Compound Library | Neuroprotective Compound Library | 2-Deoxy-D-glucose | Brefeldin A | Cytarabine | Mifepristone | Imiquimod | L-NAME hydrochloride | Ivermectin | Salubrinal | Ganciclovir | Surfactin | L-NMMA acetate | 1400W Dihydrochloride | Floxuridine | L-Arginine | Acyclovir | S-Nitroso-N-acetyl-DL-penicillamine | Methylene Blue | Ginsenoside Rb1 | Levamisole hydrochloride | Xanthohumol | Asymmetric dimethylarginine | Idoxuridine | Trifluridine | Verbascoside | Isoquercetin | Aphidicolin | Chondroitin sulfate | Guanosine | L-NIL
品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物,我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物;
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果;
• 专业团队跟踪*新的制药及生命科学研究进展,为您提供全球*新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。
更新时间:2024/1/2 10:16:38
留言咨询
温馨提示
1.遵守中华人民共和国有关法律、法规,尊重网上道德,承担一切因您的行为而直接或间接引起的法律责任。
2.请您真实的反映产品的情况,不要捏造、诬蔑、造谣。如对产品有任何疑问,也可以留言咨询。
3.未经本站同意,任何人不得利用本留言簿发布个人或团体的具有广告性质的信息或类似言论。
相关新闻
相关产品