MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

XMD8-92

CAS No. : 1234480-50-2

MCE 站：XMD8-92

产品活性：XMD8-92 是一种有效的 ERK5 (BMK1)/BRD4 抑制剂，K_d分别为80和190 nM。XMD8-92分别以190、600和890nm的 K_{ds 抑制DCAMKL2、PLK4和TNK1。具有抗癌活性。}

研究领域：MAPK/ERK Pathway  |  Stem Cell/Wnt  |  Epigenetics

作用靶点：ERK  |  Epigenetic Reader Domain

In Vitro: XMD8-92 (0-5 Μm; 48 hours) inhibits the proliferation of HMEC and cancer cells.
XMD8-92 effectively inhibits BMK1 activation as well as induces PML’s (promyelocytic leukemia protein) downstream effector, p21. XMD8-92 significantly inhibits basic fibroblast growth factor (bFGF) induced angiogenesis in Matrigel plugs. XMD8-92 significantly induces p21 expression in HeLa and A549 cells.

In Vivo: XMD8-92 (i.p.; twice a day for 28 days) significantly inhibits the growth of the xenografted human tumors.

相关产品：Bioactive Compound Library Plus  |  Epigenetics Compound Library  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  MAPK Compound Library  |  Stem Cell Signaling Compound Library  |  Histone Modification Research Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Glutamine Metabolism Compound Library  |  Anti-Blood Cancer Compound Library  |  PD98059  |  A-485  |  Curcumin  |  TBHQ  |  Birabresib  |  Tauroursodeoxycholate Sodium  |  Honokiol  |  C646  |  Ravoxertinib  |  JQ-1 (carboxylic acid)  |  Anacardic Acid  |  Astragaloside IV  |  I-BET151  |  Piperlongumine  |  SGC-CBP30  |  MG 149  |  BIX02189  |  KG-501  |  A-366  |  FR 180204  |  NSC 228155  |  Lidocaine  |  CPI-203  |  Pluripotin  |  AX-15836  |  PFI-1  |  VX-11e

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。