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产品价格:电议      采购度:1644      原产地:美洲
发布时间:2021/7/27 10:24:19 所属地区:上海 上海市
简要描述:
Barasertib-HQPA (AZD2811) 是一种高度选择性的极光激酶B抑制剂,在非细胞试验中 IC50 nM。Barasertib-HQPA (AZD2811) 对可引起癌细胞生长阻滞和凋亡。
标签:AZD2811
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CAS No. : 722544-51-6
MCE 站:Barasertib-HQPA
产品活性:Barasertib-HQPA (AZD2811) 是一种高度选择性的极光激酶B抑制剂,在非细胞试验中 IC50 值为0.37 nM。Barasertib-HQPA (AZD2811) 对可引起癌细胞生长阻滞和凋亡。
研究领域:Cell Cycle/DNA Damage | Epigenetics | Apoptosis
作用靶点:Aurora Kinase | Apoptosis
In Vitro: Barasertib-HQPA (3 μM, 3 hours) significantly decreases expression of the phosphorylated forms of histone H3 in freshly isolated leukemia cells.
Barasertib-hydroxyquinazoline pyrazol anilide (HQPA)] is converted rapidly to the active Barasertib-HQPA in plasma.
Barasertib-HQPA treatment induced defective cell survival, polyploidy, and cell death in LNCaP cell line.
Barasertib-HQPA induces a marked anti-propliferative effect accompanied by the appearance of a polyploid population, which in most cases led to apoptosis.
In Vivo: Barasertib (AZD1152, 25 mg/kg) markedly suppresses the growth and weights of AZD1152-treated tumors.
Barasertib (AZD1152, 5 mg/kg) enhances the ability of vincristine or daunorubicin to inhibit the proliferation of human MOLM13 leukemic xenografts.
Barasertib (AZD1152, (10-150 mg/kg/d) potently inhibited the growth of human colon, lung, and hematologic tumor xenografts (mean tumor growth inhibition range, 55% to z100%; P < 0.05) in immunodeficient mice.
相关产品:Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Kinase Inhibitor Library | Anti-Cancer Compound Library | Clinical Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | Anti-Blood Cancer Compound Library | MG-132 | LY294002 | Doxorubicin hydrochloride | Bafilomycin A1 | Paclitaxel | Y-27632 dihydrochloride | Acetylcysteine | Angiotensin II human | SP600125 | 5-Fluorouracil | Staurosporine | Bortezomib | Tamoxifen | 2-Deoxy-D-glucose | Gemcitabine | Verteporfin | Decitabine | Actinomycin D | Temozolomide | BAY 11-7082 | Etoposide | Mitomycin C | CCCP | DAPT | Rotenone | Etomoxir | Stattic | Docetaxel | Fulvestrant
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更新时间:2024/1/2 10:16:38
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