MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

HBV-IN-4

CAS No. : 2305897-84-9

MCE 站：HBV-IN-4

产品活性：HBV-IN-4，是一种酞嗪酮衍生物，是一种有效的具有口服活性的 HBV DNA 复制抑制剂，IC₅₀ 为 14 nM。HBV-IN-4 可诱导无基因组衣壳的形成，并具有强大的抗 HBV 效力。

研究领域：Anti-infection  |  Cell Cycle/DNA Damage

作用靶点：HBV  |  DNA/RNA Synthesis

In Vitro: HBV-IN-4 (compound 19f; 0-1 μM; 8 days) treatment inhibits the various forms (relaxed circular [rc] and single-stranded [ss] HBV DNA) in a dose-dependent manner in HepG2.2.15 cells. HBV-IN-4 treatment could also reduce capsidassociated DNAs dose-dependently. HBV-IN-4 could induce the formation of genome-free capsids, including a phenotype of faster-migrating ones.

In Vivo: HBV-IN-4 (Compound 19f; 50-150 mg/kg; oral administration; twice a day; for 4 weeks; Balb/c male mice) treatment achieves 2.67 log viral load reduction in AAV-HBV/mouse model.
HBV-IN-4 (compound 19f) exhibits favorable drug characteristics with low plasma clearance (CL=4.1 mL/min/kg), excellent drug exposure (AUC_0-t=49 744 h?ng/L), T_1/2 (2.15 hours) and oral bioavailability (F=60.4%) using 20 mg/kg oral administration in mice. HBV-IN-4 also shows good distribution in liver exposure.

相关产品：Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Cell Cycle/DNA Damage Compound Library  |  Antiviral Compound Library  |  Anti-Aging Compound Library  |  Orally Active Compound Library  |  Doxorubicin hydrochloride  |  Cycloheximide  |  Oxaliplatin  |  Gemcitabine  |  Actinomycin D  |  Mitomycin C  |  Bleomycin sulfate  |  Carboplatin  |  Cytarabine  |  Favipiravir  |  Methotrexate  |  Streptozocin  |  Anisomycin  |  Fludarabine  |  Thymidine  |  Epirubicin hydrochloride  |  Daunorubicin hydrochloride  |  Capecitabine  |  Hydroxyurea  |  OSS_128167  |  Plicamycin  |  Urolithin A  |  Brequinar  |  Folic acid  |  ML216  |  Halofuginone  |  Floxuridine  |  Triciribine

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。